Extracorporeal photopheresis reverses experimental graft-versus-host disease through regulatory T cells.

Extracorporeal Photopheresis as a Treatment of Graft-versus-Host Disease, Autoimmune Disease and Cutaneous T-Cell Lymphoma

Extracoporeal photopheresis treatment of acute graft-versus-host disease following allogeneic haematopoietic stem cell transplantation

Acute graft-versus-host disease (aGvHD) continues to be a major obstacle to allogeneic haematopoietic stem cell transplantation. Thymic damage secondary to aGvHD along with corticosteroids and other non-selective T lymphocyte-suppressive agents used in the treatment of aGvHD concurrently impair thymopoiesis and negatively impact on immunoreconstitution of the adaptive immune compartment and ult...

Extracorporeal Photopheresis for Non-skin GvHD.

Graft versus host disease (GvHD) is one of the most feared adverse events of allogeneic hematopoietic stem cell transplantation. In severe grades of GvHD patients die from infections due to impairment of their immune defense or therapy-refractory involvement of intestines, liver and lung. Extracorporeal photopheresis is an effective treatment for acute and chronic graft versus host disease with...

Extracorporeal Photopheresis: Scientific and Technical Considerations for Improving Clinical Management of Patients

Starting at the end of 90’s, and derived from PUVA therapy, arose the concept of modulation of inappropriate immune conflicts by direct action of UVA on immunocompetent cells (lymphocytes, antigen processing cells). After the inactivation of T-cells in vitro and ex vivo, was demonstrated, the development step-by-step aimed to process large amounts of the so-called peripheral mononuclear cells. ...

Compassionate use of ruxolitinib in acute and chronic graft versus host disease refractory both to corticosteroids and extracorporeal photopheresis

Background Ruxolitinib is a potent inhibitor of JAK1/2 with proven efficacy in myelofibrosis. In recent years, research in graft versus host disease (GVHD) has revealed the role of activation of JAK pathways in alloreactive lymphocytes. Some reports have shown significant responses in refractory GVHD patients. Cases presentation In this report we present our experience in 8 patients with acut...